Abstract: Objective To investigate the serum level of homocysteine (HCY) and leptin in Tibetans at Shannan area of Tibet. Methods A total of 880 Tibetan individuals who underwent routine physical examination from February 2018 to January 2021 in Shannan area of Tibet were enrolled as study subjects. Chemiluminescence method was used to compare the HCY and leptin levels among different age groups, genders, and seasons, and to study the distribution of serum HCY and leptin levels in Tibetans at Shannan area. Results With increasing age, the serum level of HCY and leptin significantly increased. The serum level of HCY and leptin in males was significantly higher than that in females (P＜0.05). Season had no significant effect on serum HCY and leptin levels (P＞0.05). The upper limits of serum HCY and leptin levels from males were 22.18 μmol/L and 7.85 μg/L respectively, while those for females were 18.01 μmol/L and 7.01 μg/L respectively. Conclusions The serum levels of HCY and leptin are significantly elevated in Tibetans at Shannan area. The risk factors found in local residents at Shannan area should be targeted in health education of local people.

Key words: Tibetans, health education, homocysteine(HCY), leptin