An update on the mechanism of neural stem cell transplantation in the treatment of Alzheimer’s disease

doi:10.16352/j.issn.1001-6325.2023.07.1148

Abstract

Abstract: At present, no effective strategy exists to slow down the progression of Alzheimer’s disease (AD). A deeper understanding of the pathogenesis of AD and the development of new therapeutic approaches are essential. Stem cell transplantation for the treatment of neurodegenerative diseases is currently a research hotspot. Numerous studies have suggested that neural stem cells (NSCs) can differentiate into functional neurons, replace dead neurons, and form synaptic connections with adjacent surviving neurons, thereby achieving a therapeutic effect. In theory, the use of NSCs to replace and restore damaged cholinergic neurons and synapses may provide a new therapeutic option for AD. This review summarizes the recent preclinical research progress of NSC transplantation for the treatment of AD.

Key words: Alzheimer’s disease, cell transplantation, neural stem cells

CLC Number:

R741.05

CHEN Xiaokun, BAO Xinjie, GAO Jun, LI Yongning. An update on the mechanism of neural stem cell transplantation in the treatment of Alzheimer’s disease[J]. Basic & Clinical Medicine, 2023, 43(7): 1148-1151.

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