Abstract: Objective To investigate the correlation between single nucleotide polymorphism (SNP) and susceptibility of chronic obstructive pulmonary disease (COPD). Methods A total of 444 COPD patients and 434 healthy people were selected as the research objects. The Sequenom MassARRAY typing was performed at four loci of chitotriosidase-1(CHIT1): rs771576027, rs1402870472, rs61745299 and rs527497633, and a site rs117292391 on phosphodiesterase 4D(PDE4D). The correlation between single nucleotide polymorphism (SNP) and the risk of COPD was statistically evaluated. Results Genotype CG and allele C of rs61745299(CHIT1) increased the risk of COPD, and the distribution frequency was significantly different (P＜0.05). Genotype AG and allele G of rs117292391(PDE4D) also increased the risk of COPD with significant, distribution frequency(P＜0.05). Smoking also increased the risk of COPD. Conclusions rs61745299(CHIT1) and rs117292391 (PDE4D) are potential candidates of COPD biomarkers.

Key words: chronic obstructive pulmonary disease, chitinase 1, phosphodiesterase 4D, single nucleotide polymorphism