Research progress on the role of secretory protein Metrnl in different diseases

doi:10.16352/j.issn.1001-6325.2022.11.1767

Abstract

Abstract: Metrnl is a new cytokine with homologous orignination from neurotrophic factor Meteorin. Meanwhile, as a secreting protein, its gene and products show low tissue specificity and is widely expressed in different tissues of host. Similar to neurotrophic factor, adipocytokines, inflammatory factor and muscle factor, the protein plays a role in neural development, immune inflammatory response and metabolism and so on.

Key words: Meteorin-like protein(Metrnl), neurotrophic factor, energy metabolism, insulin resistance, immunoregulation

CLC Number:

R335
R392.6

ZHANG Lan-yue, ZHANG Xue-dong. Research progress on the role of secretory protein Metrnl in different diseases[J]. Basic & Clinical Medicine, 2022, 42(11): 1767-1770.

References 25

[1]	Jorgensen JR, Fransson A, Fjord-Larsen L, et al. Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo[J]. Exp Neurol, 2012, 233: 172-181.
[2]	Berghoff M, Höpfinger A, Rajendran R, et al. Evidence of a muscle-brain axis by quantification of the neurotrophic myokine Metrnl (Meteorin-like protein) in human cerebrospinal fluid and serum[J]. J Clin Med, 2021, 10: 3271. doi:10.3390/jcm10153271.
[3]	Rao RR, Long JZ, White JP, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis[J]. Cell, 2014, 157: 1279-1291.
[4]	Li ZY, Song J, Zheng SL, et al. Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling[J]. Diabetes, 2015, 64: 4011-4022.
[5]	Qi Q, Hu WJ, Zheng SL, et al. Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride[J]. Acta Pharmacol Sin, 2020, 41: 1568-1575.
[6]	Ushach I, Burkhardt AM, Martinez C, et al. Meteorin-like is a cytokine associated with barrier tissues and alternatively activated macrophages[J]. Clin Immunol, 2015, 156: 119-127.
[7]	Ushach I, Arrevillaga-Boni G, Heller GN, et al. Meteorin-like/Meteorin-beta is a novel immunoregulatory cytokine associated with inflammation[J]. J Immunol, 2018, 201: 3669-3676.
[8]	Bridgewood C, Russell T, Weedon H, et al. The novel cytokine Metrnl/IL-41 is elevated in psoriatic arthritis synovium and inducible from both entheseal and synovial fibroblasts[J]. Clin Immunol, 2019, 208: 108253. doi: 10.1016/j.clim.2019.108253.
[9]	Alizadeh A, Alizadeh H. Downhill running exercise increases circulating level of myokine Meteorin-like hormone in humans[J]. J Sports Med Phys Fitness, 2021, 7: 12246-7. doi: 10.23736/S0022-4707.21.12246-7.
[10]	Eaton M, Granata C, Barry J, et al. Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and Metrnl mRNA expression in human skeletal muscle[J]. J Sport Health Sci, 2018, 7: 191-196.
[11]	Jung TW, Pyun DH, Kim TJ, et al. Meteorin-like protein (Metrnl)/IL-41 improves LPS-induced inflammatory responses via AMPK or PPARδ-mediated signaling pathways[J]. Adv Med Sci, 2021, 66: 155-161.
[12]	Lee JO, Byun WS, Kang MJ, et al. The myokine Meteorin-like (Metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2[J]. FEBS J, 2020, 287: 2087-2104.
[13]	Baht GS, Bareja A, Lee DE, et al. Meteorin-like facili-tates skeletal muscle repair through a Stat3/IGF-1 mechanism[J]. Nat Metab, 2020, 2: 278-289.
[14]	Jung TW, Lee SH, Kim HC, et al. Metrnl attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice[J]. Exp Mol Med, 2018, 50: 1-11.
[15]	El-Ashmawy HM, Selim FO, Hosny TAM, et al. Association of low serum Meteorin like (Metrnl) concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis[J]. Diabetes Res Clin Pract, 2019, 150: 57-63.
[16]	Wang K, Li F, Wang C, et al. Serum levels of meteorin-like (Metrnl) are increased in patients with newly diagnosed type 2 diabetes mellitus and are associated with insulin resistance[J]. Med Sci Monit, 2019, 25: 2337-2343.
[17]	Alkhairi I, Cherian P, Abu-Farha M, et al. Increased expression of Meteorin-like hormone in type 2 diabetes and obesity and its association with irisin[J]. Cells, 2019, 8: 1283. doi: 10.3390/cells8101283.
[18]	Hu W, Wang R, Sun B. Meteorin-like ameliorates β cell function by inhibiting β cell apoptosis of and promoting β cell proliferation via activating the WNT/β-catenin pathway[J]. Front Pharmacol, 2021, 12: 627147. doi: 10.3389/fphar.2021.627147.
[19]	Rupérez C, Ferrer-Curriu G, Cervera-Barea A, et al. Meteorin-like/Meteorin-β protects heart against cardiac dysfunction[J]. J Exp Med, 2021, 218: e20201206. doi: 10.1084/jem.20201206.
[20]	Xu L, Cai Y, Wang Y, et al. Meteorin-like (Metrnl) attenuates myocardial ischemia/reperfusion injury-induced cardiomyocytes apoptosis by alleviating endoplasmic reticulum stress via activation of AMPK-PAK2 signaling in H9C2 cells[J]. Med Sci Monit, 2020, 26: e924564. doi: 10.12659/MSM.924564.
[21]	Liu ZX, Ji HH, Yao MP, et al. Serum Metrnl is associated with the presence and severity of coronary artery disease[J]. J Cell Mol Med, 2019, 23: 271-280.
[22]	Li ZY, Fan MB, Zhang SL, et al. Intestinal Metrnl released into the gut lumen acts as a local regulator for gut antimicrobial peptides[J]. Acta Pharmacol Sin, 2016, 37: 1458-1466.
[23]	Zhang SL, Li ZY, Wang DS, et al. Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells[J]. Acta Pharmacol Sin, 2020, 41: 763-770.
[24]	Zuo L, Ge S, Ge Y, et al. The adipokine Metrnl ameliorates chronic colitis in Il-10-/- mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis[J]. J Crohns Colitis, 2019, 13: 931-941.
[25]	Gholamrezayi A, Mohamadinarab M, Rahbarinejad P, et al. Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines[J]. Lipids Health Dis, 2020, 19: 230. doi: 10.1186/s12944-020-01404-6.