Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases

doi:10.16352/j.issn.1001-6325.2022.07.1119

Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (7): 1119-1123.doi: 10.16352/j.issn.1001-6325.2022.07.1119

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Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases

LUAN Ge^1,2, WANG Ming^1,2, WANG Cheng-shuo^1,2*, ZHANG Luo^{1,2, 3*}

1. Department of Otolaryngology Head and Neck Surgery, Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education; 3. Department of Allergology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730;
2. Beijing Institute of Otolaryngology, Beijing Key Laboratory of Nasal Diseases, Beijing 100005, China

Received:2021-01-26 Revised:2021-07-12 Online:2022-07-05 Published:2022-06-29
Contact: * dr.luozhang@139.com;wangcs830@126.com

Abstract

Abstract: Interferon regulatory factor 4 (IRF4) is expressed in a variety of immune cells and participates in the regulation of a variety of immune responses. IRF4 is related to a variety of chronic inflammatory diseases and respiratory allergic diseases. Inhibiting the expression or the function of IRF4 can reduce or delay the occurrence and development of the disease. Studying the role and mechanism of IRF4 in chronic rhinopathy and airway allergic diseases will help provide new strategies for disease treatment.

Key words: interferon regulatory factor 4, chronic inflammatory disease, respiratory allergic disease, immune regulation

CLC Number:

R392

LUAN Ge, WANG Ming, WANG Cheng-shuo, ZHANG Luo. Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases[J]. Basic & Clinical Medicine, 2022, 42(7): 1119-1123.

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Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases

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