Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (4): 675-678.doi: 10.16352/j.issn.1001-6325.2022.04.009

• Mini Reviews • Previous Articles     Next Articles

Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction

RONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang*   

  1. Department of Anesthesiology,Peking University Third Hospital,Beijing 100191,China
  • Received:2020-12-09 Revised:2021-06-15 Online:2022-04-05 Published:2022-04-01
  • Contact: * puthmzk@hsc.pku.edu.cn

Abstract: The dynamic balance between DNA double-strand break (DSB) accumulation and repair is one of the important factors to maintain genomic stability. The homologous recombination (HR) and the non-homologous ending joining (NHEJ) are the two major pathways to repair DSB.In mature neurons of the central nervous system, the NHEJ is the main repair pathway of DSB.Recent studies in the molecular mechanism of NHEJ and peri-operative cognitive dysfunction (POCD) revealed several molecular mechanisms underlying the DNA damage repair and its links to POCD, which may provide a new therapeutic target.

Key words: DNA damage repair, non-homologous end joining, perioperative cognitive dysfunction

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