Abstract: Objective To investigate the application of the consciousness index 1(IoC1) combined with injury sensitive index 2(IoC2) in cesarean section under general anesthesia. Methods Sixty patients underwent cesarean section under general anesthesia, ASA grade Ⅰ-Ⅱ, aged 18-42. They were randomized into control group (C group); in which depth of anesthesia and intensity of analgesia were evaluated by traditional monitoring, and consciousness index IoC1 combined with injury sensitive index IoC2 group (IoC group) in which IoC1 and IoC2 were used to guide by the depth of sedation and the intensity of analgesia. Mean arterial pressure (MAP) and heart rate (HR) were recorded. The incidence of the HR and MAP fluctuations≥±20% of the baseline, the dosage of propofol, the dosage of remifentanyl and neonatal Apgar score, anesthesia time, wake up time of the two groups were compared. Postoperative pain scores, nausea, vomiting, and intraoperative awareness were compared. Results Compared with the T0 time point, HR and MAP were significantly decreased in two groups at time point T1, HR and MAP in the C group were significantly increased at the time points T2 and T3, and significantly decreased at the end of the operation (T4) (P＜0.05). HR and MAP in IoC group increased significantly only at the time point T2. Compared with C group, propofol dosage, remifentanil dosage and the recovery time in the IoC group were significantly reduced, and the incidence of HR and MAP fluctuations beyond 20% of the baseline, postoperative nausea and vomiting were significantly reduced (P＜ 0.05). Conclusions During the general anesthesia for cesarean section, the IoC1 and IoC2 can reflect the level of consciousness and degree of analgesia well. It can monitor the depth of anesthesia and guide the perioperative anesthesia better, shorten the recovery time of anesthesia, make hemodynamics more stable, reduce postoperative complications, and improve the quality of obstetric anesthesia.

Key words: consciousness index, injury sensitivity index, cesarean section