The anti-Candida albicans infection of mouse by extracellular polysaccharide from PH1008

Abstract

Abstract: Objective To evaluate the anti-infective effect of polysaccharide isolated from fungus PH1008 in vaginal Candida albicans infection model of mouse,and to provide a new and potential pathway to the development of anti-candida drugs. Methods Determination of gene expression level of transcriptome in mice vagina after yeast infection mouse model was treated by exopolysaccharide of fungus PH1008. Results The expression of hepatocyte growth factor and complement 1 receptor was increased, and the up-regulation was related to varied signal transduction pathways. Conclusions The anti-infection effect of Candida albicans can be induced by vaginal mucosal immunization with exopolysaccharide of fungus PH1008, and the relevant mechanism needs further research.

Key words: mangrove fungus, infection, vagina

CLC Number:

WANG Ying, BEI Ning, PEI Hua, YANG Wen, WANG Hua-min. The anti-Candida albicans infection of mouse by extracellular polysaccharide from PH1008[J]. Basic & Clinical Medicine, 2021, 41(2): 155-158.

References

[1] Sun MG, Huang Y, Xu YH, et al. Efficacy of vitamin B complex as an adjuvant therapy for the treatment of complicated vulvovaginal candidiasis: an in vivo and in vitro study[J]. Biomed Pharmacother, 2017, 88(Complete): 770-777.
[2] Zeng X, Zhang Y, Zhang T, et al. Risk factors of vulvovaginal candidiasis among women of reproductive age in Xi'an: a cross-sectional study[J]. Biomed Res Int, 2018, 2018:1-8.
[3] 孙明伟, 丁艳娇, 鲁春华, 等. 海南红树林根际糖多胞菌菌株YIMM135 68的红霉素类抗生素的分离和鉴定[J]. 中国抗生素杂志, 2017,42:346-350.
[4] 王永霞, 黄燕妮, 李国军, 等. 海南红树林淡紫拟青霉EPS纯化物体外抗HSV-1实验研究[J]. 海南医学院学报, 2016, 22:2217-2220.
[5] Yang L, Wu H, Qiu W, et al. Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the dectin-1 signaling pathway[J]. J Ethnopharmacol, 2018, 223:51-62.
[6] Zheng YF, Zhang Q, Liu XM, et al. Extraction of polysaccharides and its antitumor activity on magnolia kwangsiensis figlar & noot[J]. Carbohydr Polym, 2016, 142:98-104.
[7] Ilhem R, Anouar F, Anouar BS, et al. Lycium europaeum, linn as a source of polysaccharide with, in vitro, antioxidant activities and, in vivo, anti-inflammatory and hepato-nephroprotective potentials[J]. J Ethnopharmacol, 2018,8:116-127.
[8] 潘峰, 姚芸欣, 唐鑫, 等. 瓦布贝母内生真菌Fusarium redolens 6WBY3多糖的理化性质及抗氧化活性[J]. 微生物学报, 2017, 57:240-253.
[9] Guo Z, Gai C, Cai C, et al. Metabolites with insecticidal activity from asper-gillus fumigatus JRJ111048 isolated from mangrove plant acros-tichum specioum endemic to Hainan island[J]. Mar Drugs, 2017,15:381.
[10] Pavan KJ, Ajitha G, Gothandam K. Bioactivity assess-ment of Indian ori gin—mangrove actinobacteria against Candida albicans[J]. Mar Drugs, 2018, 16:60.
[11] Rahman M,Segal BH. Thematic issue: immunity, inflammation and fungal infections[J]. Immunological Investigations, 2001,40:670-675.
[12] Verma A, Wuthrich M, Deepe G, et al. Adaptive immunity to fungi[J]. Cold Spring Harb Perspect Med, 2015, 5.doi:10.1101/cshperspect.a019612.

[1]	SONG Boyuan, WU Xueli, LI Xueyuan, WANG Lisha, CHEN Yang. Dynamic transcriptomic analysis of macrophages infected with Salmonella typhimurium [J]. Basic & Clinical Medicine, 2024, 44(6): 779-785.
[2]	LIU Yuhao, ZHANG Yueyi, BAI Xiaoyin, CHEN Yang, ZHOU Weixun, LI Xiaoqing. A case of visceral myopathy with ATCG2 gene mutation misdiagnosed as Hirschsprung disease [J]. Basic & Clinical Medicine, 2024, 44(6): 873-876.
[3]	SONG Min, ZHANG Yuping, ZHU Ping, YANG Qiuhong, ZHANG Suxia, LIU Cuiying, LIU Yanping. Effect of oral probiotics on vaginal microbiota in patients with vaginitis during pregnancy [J]. Basic & Clinical Medicine, 2024, 44(5): 714-718.
[4]	ZHANG Yi, SHEN Le. Postoperative complications and related risk factors in COVID-19 patients [J]. Basic & Clinical Medicine, 2024, 44(3): 408-411.
[5]	DAI Jingrong, XIAO Bao, LI Lin, HU Jiangying, LIU Bin. Factors affecting nosocomial death in elderly patients with COVID-19 and construction of a risk predictive model [J]. Basic & Clinical Medicine, 2024, 44(1): 92-97.
[6]	ZHAO Lu, LIU Yang. γ-Aminobutyric acid promotes vesicular stomatitis virus infection in mouse macrophages [J]. Basic & Clinical Medicine, 2023, 43(6): 936-940.
[7]	KANG Bibo, ZHAO Rong, ZHAO yang, SHEN Huanjun, CHEN Zhaoxia, ZHOU Yun, FAN Chao. Correlation of serum B cell-attracting chemokine 1 and stem cell factor with clinical indices of HBV infected patients [J]. Basic & Clinical Medicine, 2023, 43(2): 289-292.
[8]	ZHU Li-ru, HUANG You-ming, ZHANG Hong-xiang, ZHOU Fa-you, TANG Xiao-lei. Prokaryotic expression of glucans binding protein and application for detecting invasive fungal infection [J]. Basic & Clinical Medicine, 2022, 42(6): 883-889.
[9]	DU Xin-yi, MAO Xiao-rong, LI Jun-feng. Application of anti-HBc quantitative examination in clinical management of chronic hepatitis B virus infection [J]. Basic & Clinical Medicine, 2022, 42(5): 804-808.
[10]	ZHANG Ying-qi, HUANG Yu-zhu, PAN Ming-hu, GUO Xiu-ling, LIU Li. Reduction of lung infection rates after cardiac surgery with target monitoring [J]. Basic & Clinical Medicine, 2022, 42(11): 1760-1763.
[11]	ZHONG Yi-feng, SONG Ying-na, TANG Ping-ping, YIN Jie. Evaluation of hands-on instruction versus video demonstration for vacuum delivery training [J]. Basic & Clinical Medicine, 2021, 41(6): 918-922.
[12]	XIA Di, XU Li, LI Xu, HUANG Yu-guang. Goal-directed fluid therapy optimizes hemodynamics on the elderly patients undergoing lumbar decompressive surgery and reduces postoperative complications [J]. Basic & Clinical Medicine, 2021, 41(2): 178-183.
[13]	FENG Xiao-kai, HE Huai-wu, ZHANG Jia-hui, CHENG Wei, LONG Yun, GUO Fu-ping. A rare case of blood stream infection caused by yeast-Rhodotorula glutinis [J]. Basic & Clinical Medicine, 2021, 41(11): 1658-1661.
[14]	XU Hui-juan, LIU Kun, ZHENG Jing-mei, JIANG Qiu-li, LU Hua-dong, XU Jian-fang. Human papilloma virus (HPV) infection and cervical lesions screened in 3 144 women at Xiamen, Fujian province, China [J]. Basic & Clinical Medicine, 2021, 41(11): 1643-1647.
[15]	MENG Wei, WANG Ruo-jiao, LYU Ke, ZHANG Yi-xiu, LI Jian-chu, LI Wen-bo, WANG Ming. Disinfection of ultrasonic equipment in non-isolated diagnosis area in COVID-19 epidemic situation [J]. Basic & Clinical Medicine, 2020, 40(9): 1261-1265.