Abstract: Objective To study the relationship between glycated albumin (GA), glycated hemoglobin (HbA1c), GA/HbA1c ratio and NAFLD in patients with type 2 diabetes and non-alcoholic fatty liver. Methods A total of 502 patients with type 2 diabetes hospitalized from February to December 2017 were divided into 281 cases of type 2 diabetes and 221 cases of type 2 diabetes complicated with NAFLD based on the presence or absence of NAFLD. The correlation biochemical indexes, GA, HbA1c and GA/HbA1c were compared between the two groups using t test and rank sum test, and the correlation analysis of GA/HbA1c ratio and regression analysis of influencing factors of type 2 diabetes combined with NAFLD were performed. Results GA/HbA1c in T2DM complicated with NAFLD group was higher than that in T2DM group(P＜0.05). GA/HbA1c was positively correlated with GA, CRP and FPG(P＜0.05), and negatively correlated with fasting C-peptide(P＜0.05). Logistic regression analysis showed that GA and GA/HbA1c were risk factors for T2DM complicated with NAFLD(P＜0.05). ROC curve: area under the curve of GA/HbA1c was 0.745, area under the curve of GA was 0.660. Conclusions GA/HbA1c is an independent risk factor for T2DM complicated with NAFLD.

Key words: type 2 diabetes mellitus, nonalcoholic fatty liver, glycated albumin, glycated hemoglobin