Abstract: Virtual simulation experiments have become an important part of the informatics-based high education. This paper described the training of virus inoculation into chichen embryos by virtual simulation to avoid potential biological risk in classic experiment. In order to support students learning of basic techniques in microbiology, a cooperative learning using the jigsaw approach had been explored. Under the guidance of student-centered strategy At the same time, the evaluation of learning outcome was developed. Our goal was to construct a hybrid online and offline training system. Student's learning initiative and the experimental training outcomes have been significantly improved. In addition, this new system also facilitates the integration of education on professionalism/competence and humanity spirit into laboratory technology training.

Key words: virtual simulation experiment, virus, medical microbiology, jigsaw, blended teaching