Abstract: Objective To ensure the newly admitted patients with non-COVID-19 infection to be well protected through setting up buffer quarantine area in designated hospitals. Methods For safety of the admission of patients with infectious diseases in Yichang Third People's Hospital, a buffer quarantine area was set up,pathway for outpatient and emergency patients entering management process of diagnosis and treatment was established. Through the outpatient pre-screening and triage, the non-COVID-19 and COVID-19 patients were preliminarily identified. Newly admitted patients with non-coronavirus infectious diseases were managed in separated rooms. Then they were divided into specialized infectious disease areas through a six-day health monitoring and standardized screening. Results The establishment and operation of the buffer quarantine area ensured the regular treatment of patients with other infectious diseases during the COVID-19 pandemic, and prevented cross-infection to medical staff and other patients. At the same time, by buffering and isolating the ward, centralized treatment reduced the investment of human resources and protective materials, which was more conducive to standardized management. Conclusions The setting up of the centralized management of the buffer quarantine area can protect the patients with other infectious diseases and provide them with qualified treatment.

Key words: COVID-19, buffer quarantine area, cross infection