Abstract: Objective To evaluate the value of combined detection of serum C-reactive protein (CRP) and procalcitonin (PCT) for early warning of traumatic sepsis. Methods Two hundred and thirty five patients with severe trauma were included, including 110 patients with sepsis and 125 patients with non-sepsis.Blood samples were collected in 24 hours of admission and serum CRP and PCT were measured. The ROC curve was used to compare the early warning value of CRP and PCT for post-traumatic sepsis, and the improvement ability after combined use of NRI and IDI was analyzed. Results The results showed that CRP and PCT in patients with post-traumatic sepsis were significantly higher than those in non-sepsis patients (P＜0.001). ROC analysis revealed that the AUC of serum CRP and PCT were 0.766 (0.707-0.819) and 0.744 (0.684-0.799), respectively; The AUC of CRP and PCT combined with single-label early warning trauma sepsis was increased by 5.1%, 7.3%.Meanwhile, the results of NRI and IDI analysis also suggested the combination of CRP and PCT was sensitive to identify the patients with high risk of sepsis (P＜ 0.001). Conclusions CRP and PCT have early prediction effects on the risk of sepsis in major trauma patients. Combination of CPR and PCT can significantly improve early prediction ability.

Key words: traumatic sepsis, C-reactive protein, procalcitonin, early prediction