Research progress in the regulation of bone homeostasis by long noncoding RNAs

Abstract

Abstract: Bone formation and bone resorption are two important processes of bone homeostasis maintenance, and the imbalance of bone homeostasis can lead to a variety of bone metabolic diseases. Long noncoding RNAs (lncRNAs) are a subset of RNAs with only rarely encoding proteins and play important regulatory role in regulation of gene expression, life development and disease occurrence.In bone metabolic diseases, lots of lncRNAs are abnormally expressed. LncRNAs regulate bone formation process through regulating chondrogenic differentiation, osteogenic differentiation and bonematrix mineralization. By affecting the differentiation and maturation of osteoclasts,lncRNAs are involved in the regulation of bone resorption.

Key words: long noncoding RNAs, bone homeostasis, bone formation, bone resorption

CLC Number:

R681

FAN Lin-yuan, LI Hong-ling. Research progress in the regulation of bone homeostasis by long noncoding RNAs[J]. Basic & Clinical Medicine, 2020, 40(1): 115-119.

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