Abstract: Objective To investigate the effect of leukotriene-mediated inflammatory injury on hypersecretion of airway mucus in asthmatic rats.Methods The rat model of asthma was duplicated with OVA classic modeling method, and the CysLTs1 specific receptor antagonist montelukast was used for ELISA、Western blot and q-PCR to observe the changes of inflammation and airway mucus secretion indexes.Results Montelukast could inhibit CysLTs receptor 1,P38MAPK phosphorylation, and down-regulate MUC5AC gene expression and protein synthesis. Conclusions Leukotriene-mediated inflammation is shown to promote airway mucus hypersecretion in asthmatic rats, which could be antagonized by montelukase.

Key words: montelukast asthma hypersecretion of airway mucus