Abstract: Objective To investigate the value of skin sympathetic reflex, anal sphincter electromyography and blink reflex in the diagnosis of Parkinson's disease. Methods Fifty patients with Parkinson's disease were selected from Jinhua Central Hospital, according to the evaluation of neurologic function, the patients were divided into two groups: no autonomic nerve dysfunction (PD-NAS) group（thirty-five cases）and autonomic nervous dysfunction (PD-AS) group （fifteen cases）. Another fifty healthy health examiners were selected as the control group. Parkinson's autonomic symptoms were scored in all groups, and skin sympathetic reflex, anal sphincter electromyography and blink reflex were measured at the same time. The correlation between Parkinson's autonomic symptom score and skin sympathetic reflex, blink reflex and anal sphincter electromyograms were analyed. Results The average score of SCOPA-AUT in PD-AS group was significantly higher than that in PD-NAS group (P < 0 05), and it was also significantly higher than that in control group (P < 0 05). The skin sympathetic reflex (SSR) of patients in PD-AS group was prolonged the latency and decreased the amplitude compared with the control group (P<0.05). The mean time and polyphasic percentage of motion unit of anal sphincter during slight contraction(MUAP) in PD-AS group were significantly higher than those in PD-NAS group, the difference was statistically significant (P<0.05). In the PD-AS group, the latency of R2 and R2' waves was longer than that of the PD-NAS group (P<0.05). In PD-AS group, the amplitude of SSR in upper and lower extremities was positively correlated with the latency of SSR in the upper and lower extremities (P<0.05), and the SCOPA-AUT score was positively correlated with the average duration of MUAP and the percentage of multiphase waves (P<0.05). Conclusions Skin sympathetic reflex, blink reflex and anal sphincter EMG can reflect the severity of autonomic dysfunction in patients with Parkinson's disease and provide a basis for early diagnosis of Parkinson's disease.

Key words: Parkinson's disease, Skin Sympathetic Reflex, External anal sphincter electromyography, Blink reflection