Abstract: The late antigen 4(VLA-4) and the vascular cell adhesion molecule 1(VCAM-1) are ligands to each other, and the late antigen 4 can specifically bind to the first domain or the fourth domain of the vascular cell adhesion molecule1,and six linear amino acid sequences found in domain 1 and domain 4 of vascular cell adhesion molecules, and this sequence plays a crucial role in the specific binding of the two.Advanced antigen-4 and vascular cell adhesion molecule-1 are highly expressed in many diseases and are inextricably linked to the pathogenesis of many diseases.

Key words: VCAM-1, VLA-4, NF-κB, tumour