Abstract: GATA-binding protein 3 (GATA3) plays an important role in regulating lymphocyte differenciation, promoting naive T cells to differeciate towards TH2 direction and supressing the differentiation of B lymphocyte or myeloid cells. Mutation or abnormal expression of GATA3 drices the development and progression of lyphoid malignancies through affecting tumor microenvironment and transmitting false effects frm other signal pathways. GATA3 expression is a prognostic marker in peripheral T-cell lymphoma. The research on medication targetting GATA3 has shown a great future.

Key words: GATA-binding protein3, TH2 cell, T cell lymphoma , hematological malignancy