Abstract: Long non-coding RNAs(lncRNAs) which are defined as RNAs of more than 200 nucleotides in length don’t encode protein. LncRNAs are closely related to the development of breast cancer.Plenty of lncRNAs are dysregulated in breast cancer,and they can regulate the invasion and metastasis of breast cancer through various mechanisms such as transcription and post-transcriptional regulation which is greatly important to guide the treatment and prognosis of breast cancer.

Key words: Long non-coding RNA, breast cancer, invasion and metastasis