Abstract: Objective To explore the effects of Astragalus polysaccharides on liver injury induced by cadmium chloride. Methods The cadmium chloride solution was administrated by intraperitoneal injection to prepare the rat models of liver injury, Rats were randomized divided into three groups: control group, model group, Astragalus polysaccharides intervention group. After the 5 weeks, the rats were sacrificed and the liver was removed. The liver index was calculated by weighing method, the levels of glutamic pyruvic transaminase(ALT) 、glutamic oxalacetic transaminase(AST) and lactate dehydrogenase(LDH) were detected by colorimetric assay, the contents of cadmium(Cd) was checked by Inductively coupled plasma mass spectrometerthe(ICP-MS), the contents of interleukin-2(IL-2) and transforming growth factor-β1 (TGF-β1) was measured by ELISA, the the protein expressions of Bcl-2 and Bax were observed by immunohistochemistry staining method. Results Compared with the control group, the liver index was increased in model group, the levels of ALT、AST and LDH were also ascended in model group, the contents of Cd、TGF-β1 and the protein expression of Bax were all increased evidently in mode group(P<0.05 or P<0.01); But, the content of IL-2 and the protein expression of Bcl-2 were decreased in mode group(P<0.05 or P<0.01). Compared with the model group, the liver index was decreased in Astragalus polysaccharides intervention group, the levels of ALT、AST and LDH were also reduced in Astragalus polysaccharides intervention group, the contents of Cd、TGF-β1 and the protein expression of Bax were all dropped in Astragalus polysaccharides intervention group(P<0.05 or P<0.01); But, the content of IL-2 and the protein expression of Bcl-2 were increased in Astragalus polysaccharides intervention group(P<0.05 or P<0.01). Conclusion Astragalus polysaccharides could reduce the oxidative stress injury of rats liver cells indued by cadmium chloride, and its mechanism may be achieved by the regulation of Bcl-2/Bax protein expression.