Abstract: In order to improve the teaching quality of the clinical epidemiology course for medical students of the eight-year medical education program in Peking Union Medical College, and foster the practice of evidence-based medicine and clinical research in Peking Union Medical College Hospital (PUMCH), the Clinical Epidemiology Unit of PUMCH (PUMCH-CEU) borrowed successful experience from foreign faculties and conducted a teaching reform. In addition to theory teaching, PUMCH-CEU incorporated literature case study and assignments into the course, so as to improve students’ understanding about the design, measurement, and evaluation of clinical research. The execution of a well-designed reformation plan has led to a great success of this course, as well as fruitful achievements.

Key words: eight-year medical education program, clinical epidemiology, teaching reformation, literature case teaching