Abstract: SIRT are a family of highly conserved nicotine adenine dinucleotide（NAD+）-dependent protein deacetylase, regulating several processes including cell gene stability, metabolism, aging and apoptosis. Studies have shown that SIRT has protective effects on intestinal barrier, which influences the structure and function of intestinal barrier by controlling the release of inflammatory cytokines, regu-lating the expression of tight junction protein in intestinal epithelial, and changing the number of Paneth and goblet cells in the intestine.

Key words: SIRT, protein deacetylase, intestinal barrier