Abstract: Objective To develop an appropriate new model on the basis of current teaching and researches in the teaching of Medical Microbiology. Methods Totally 457 third grade students in Peking Union Medical College were enrolled in the project of learning Medical Microbiology. Anonymous questionnaires were used to investigate the subjective feelings of students for frame-work based learning(FBL), performance of students during FBL presentation were evaluated using concerned tables, the distribution of different topics involved in FBL self-oriented(ORL) learning was also analyzed. And simultaneously, students’ subjective feeling and suggestion were collected. And additionally, the effects of three different teaching/learning methods underlying FBL were investigated by objective tests. With that we developed a preliminary design of teaching model in Medical Microbiology. Results Scores of anonymous evaluation of FBL ranged from （2.54±0.74）to（3.43±0.56）, and scores in the evaluation of FBL presentation ranged from （4.22±0.32）to（4.77±0.22）.Percentages of topics involved in non-Medical Microbiology curriculums were respectively 21.43%, 7.14%, 38.89%, 57.14%, 33.33% and 38.89% in 6 grades from 2008 to 2013. Conclusions In the teaching of Medical Microbiology, FBL exhibited good effects for students performance in presentation and a potential populization in the learning of other medical courses besides Medical Microbiology. Recent studies indicated that blended teaching model including traditional methods, peer education, ORL based on FBL may exert better influence on students’ learning.

Key words: frame-work based learning, self-oriented learning, blended teaching model