Abstract: Objective To estimate outcome and prognostic risk factors of special type endometrial cancer. Methods Clinic data was collected in PUMCH during 2005-2010. SPSS software was used to analyze data. Logistic regression analysis were used to analyze prognostic risk factors respectively. Results Medium follow up time of total 48 endometrial serous carcinoma, clear cell carcinoma and carcinosarcoma patients was 70.5 months. Most of patients could be diagnosed at early time(FIGO I stage and II stage were 66.7% among all patients). The main treatment was operation and followed by chemo-therapy and radio-therapy. 66.7% of patients accepted chemo-therapy after operation, and 41.7% of patients accepted radio-therapy. The outcome of advanced patients was poor. 30.8% stage III relapsed and died in 3 years. The recurrence rate and mortality were all 100%. The recurrence rate of advance endometrial serous carcinoma was 80%, which was much higher than the other two. FIGO stage and lymphatic metastasis were the main prognostic risk factors. Conclusions The outcome of special type endometrial cancer is poor. Lymphatic metastasis affects prognosis.

Key words: endometrial carcinoma, serous carcinoma, clear cell carcinoma, carcinosarcoma