Abstract: When face various environment stimulation ,eukaryotic cells form some dense granules in hyalomitome ,that are stress granules(SGs).They have function of antioxidant and inhibit apoptosis. Interactions between mRNA-binding proteins promote stress granule formation. Assembly and disassembly of stress granules are modulated by various post-translational modifications as well as numerous ATP-dependent RNP or protein remodeling complexes.Stress granules have the ability of liquidity，and energy input is required to maintain their dynamic state.Stress granule formation can regulate the process of stress reaction, virus infection and the signal transduction.The formation of constant and the abnormal stress granules result in neurodegenerative diseases and certain types of cancer.

Key words: stress response, stress granules, ribosome, dynamic state, disease