Abstract: Objective To investigate the effects of chronic intermittent hypoxia and on GLUT-2, IRS-2 expression in the rat kidney. Methods Rats were randomly divided into control group (control), chronic intermittent hypoxia group (CIH), chronic intermittent hypoxia reoxygenation group (RH), the establishment of chronic intermittent hypoxia animal models,arterial blood gas analysis were extracted immediately.Serum glucose was measured by peroxidase and serum insulin was detected by radioimmunoassay. Remove the kidney tissue of rats ,protein expression of GLUT-2, IRS-2 were detected with Western Blot and immunohistochemical,mRNA expression of GLUT-2、IRS-2 were observed by qPCR . Results Oximetry in the control group was ≥95%, oxygen saturation in the CIH group was ≤85%, oxygen saturation in the RH group was ≥86%; fasting blood glucose , serum insulin and insulin resistance index in the CIH group were significantly higher than the control group and RH group (P <0.05); RH group was higher than control group (P <0.05). protein and mRNA expression of GLUT-2、 IRS-2 in the CIH group were higher than the control group and RH group (P <0.05); RH group was higher than control group (P <0.05). Conclusion Chronic intermittent hypoxia can increase blood glucose，upregulates the expression of GLUT-2, IRS2 in the rat kidney and enhance insulin resistance and decreased insulin sensitivity.

Key words: chronic intermittent hypoxia, insulin resistance, glucose metabolism, glucose transporter 2, insulin receptor substrate 2