Subcellular localization of tumor-inhibiting factor PTEN in ischemia-anoxia brain damage

Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (12): 1718-1722.

Subcellular localization of tumor-inhibiting factor PTEN in ischemia-anoxia brain damage

Received:2016-02-19 Revised:2016-04-28 Online:2016-12-05 Published:2016-11-29
Contact: Jing ZHAO E-mail:zhaojinga@yeah.net

Abstract

Abstract: Phosphatase and tensin homologue deleted on chromosome 10（PTEN）is a protein contains lipid and protein phosphatase activity. The activation of PTEN and increased mitochondria or nuclear translocation after ischemia-anoxia in brain may determin the fate of neurons. Therefore, elucidation the molecular mechanisms of subcellular localization of PTEN after ischemia-anoxia would provide new insights in the target therapy of a large number of acute/chronic neurodegenerative disorders and drug design.

Key words: PTEN, ischemia, anoxia, neuron, subcellular localization

CLC Number:

R722

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Subcellular localization of tumor-inhibiting factor PTEN in ischemia-anoxia brain damage

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