Abstract: Objective To investigate the trend of the clinic distribution and antibiotic resistance of Klebsiella pneumoniae,and to provide the reasonable clinical application scheme of antibiotics. Methods To analyse the antibiotic resistance of 2,499 isolates of klbsiella pneumoniae from clinical samples collected in our hospital during the period of 2013-2015.Results The Klebsiella pneumonia-positive specimens were mostly derived from sputum(52.7%), urine(12.28%), and blood(10.04%). The rates of resistance for cephalosporins and penicillins were above 80%. As for carbapenems,clinical isolates of Klebsiella pneumoniae have still displayed high degrees sensitivity for tigecycline and ertapenem, while the resistance rate for imipenem was incresing,The rates of multidrug resistance in 2,499 strains isolated in 2013- 2015 were 24.45% which was higher than before.Conclusion: Accordding to the changing of drug resistance of Klebsiella pneumoniae, for effectively to control the production of resistant bacteria and reduce the rate of drug resistance,we take augnt to the early warning guidance of antimicrobial agents in time and using of antibiotics rationally.

Key words: Klebsiella pneumoniae, Antimicrobial agents, Multiple resistance