Abstract: Objective:To explore the expression and significance of C-erbB-2 and vascular endothelial growth factor (VEGF) in sinonasal squamous cell carcinoma（SNSCC）. Methods: Immuno -histochemical method and Western blot method was used to determine the expression of C-erbB-2 and VEGF in specimen of sixty-two cases of sinonasal squamous cell carcinoma(SNSCC) ，thirty cases of nasal polyps﹙NP﹚and twenty-five cases of normal nasal mucosa. Results：The expression of C-erbB-2 and VEGF in SNSCC significantly higher than that in nasal polyps﹙NP﹚and normal nasal mucosa（P﹤0.05）. Furthermore，the expression of C-erbB-2 and VEGF correlated with tumor classification，clinicopathologic stage，lymph node involvement（P﹤0.05），but not with patient’s age and gender.Conclusion: C-erbB-2 and VEGF are closely related to the tumorigenesis，differentiation and proliferation of SNSCC.Detection of these protein combined helps to diagnose and treatment of SNSCC.

Key words: Sinonasal neoplasms, squamous cell carcinoma, C-erbB-2, vascular endothelial growth factor, Immunohistochemical method, Western Blot