Abstract: Diabetic neuropathic pain (DNP) and itch are the well-known complications of diabetes. Despite much advances in diabetes complications, the exact mechanisms of diabetic neuropathic pain and itch are still not clear. In this review, we discuss various possible mechanisms of the pathogenesis of neuropathic pain and itch, including the role of hyperglycemia in altering the physiology of peripheral nerves and other mechanisms of diabetic neuropathic pain and itch.

Key words: Diabetic, Hyperglycemia, Neuropathy, Skin lesions