Abstract: Objective To evaluate the residents’ status of peripheral red blood cell in hexavalent chromium areas. Methods 135 residents in Jinzhou were randomly selected nearby an alloy plant with 50 years of hexavalent chromium by cluster sampling method. We conducted a questionnaire-based survey and gather blood and urine sample.Results By using robust regression model adjusted for age, sex, smoking, drinking and BMI, we find association of chromium in urinary with RBC （β=-0.09，P<0.01），MCH（β=1.71，P<0.01） and MCV（β=0.29，P<0.05）respectively. Furtheranalysis showed thatMCV’s relation with urinarychromium limited to individualsyounger than 60.Theassociation with RBC was only seen forwomen and the association with MCHC was only seen for men. Conclusion Exposure to hexavalent chromium in the environment have chronical impact to peripheral red blood cell.

Key words: hexavalent chromium, pollution, environmental exposure, peripheral red blood cell