Abstract: Adrenal medulla tumors have been reported associated with 18 kinds of somatic and germline genes mutation. With the development of genomics and proteomics, recent findings reveal the pathogenesis of adrenocortical tumor and new marks for the adrenocortical carcinoma prognosis. Mitotane as the essential drug to the adrenocortical carcinoma combine with etoposide, doxorubicin and cisplatin will improve progression-free survival.

Key words: Adrenal tumor, pheochromocytoma, aldosterone-producing adenoma, cortical-producing adenoma, adrenocortical carcinoma