Abstract: Objective To explore the effect of early estrogen replacement therapy on bone mineral density (BMD) in patients with Turner syndrome（TS）.Methods 27 TS patients were selected from Nanism Clinic of Endocrinology Department of Peking Union Medical College Hospital from August 2005 to August 2015. Heights and weights were measured in all patients. The BMD was measured by dual-energy X-ray absorptiometry(LUNAR-PRODGIY Type).We compared the BMD before and after estrogen replacement therapy in patients with TS and the effects on BMD of the starting age of estrogen treatment. Results Estrogen treatment after one year, 1～3 years,> 3 years ,L2-4 BMD were (0.96±0.13) g/cm2、(0.92±0.13) g/cm2 and( 0.93±0.14) g/cm2 respectively, significantly higher than baseline(0.73±0.08) g/cm2、(0.70±0.13) g/cm2 and (0.75±0.07) g/cm2.The BMD L2-4 of whose estrogen therapy was initiated < 18 years group (0.96±0.14) g/cm2was significantly higher than the girls who started estrogen therapy ≥ 18 years group (0.90±0.10) g/cm2.Conclusions Early estrogen replacement therapy can effectively improve BMD in patients with TS, but other factors affecting BMD still need to be further explored.

Key words: Key words: Turner syndrome, estrogen, bone mineral density