Abstract: IKKε known as a new IκB kinase(IKK)-related kinases play a vital role in regulating inflammation, innate immune response and oncogenesis through the activation of non-canonical NF-κB and IRF signaling cascades. Meanwhile, the role involved in the pathophysiology of metabolic diseases have gradually been found. IKKε have been closely linked to obesity, type 2 diabetes(T2DM)and non-alcoholic fatty liver disease（NAFLD）through the mechanism including producing inflammation, aggravating insulin resistance and effecting energy expenditure as well as andipokines secretion.

Key words: IKKε , type 2 diabetes, non-alcoholic fatty liver disease