Abstract: As we know, calcium overload, oxidative stress, apoptosis and autophagy can induce myocardial ischemia reperfusion injury(MIRI).In addition, microRNAs, TLRs and other molecules also play an important role in MIRI. These mechanisms contact and interact with each other. The treatment of MIRI is no longer medication singly. Ischemic preconditioning, new drugs targeted small molecules, gene therapy and other new measures gradually go from bench to bedside.

Key words: myocardial ischemia reperfusion injury, mechanism, therapy