Abstract: The multiplex ligation-dependent probe amplification (MLPA) technology used in detection of gene deletions/duplications not only helps in understanding the molecular mechanisms underlying the development of cancer, but also provides important information for disease diagnosis and prognosis. Currently, MLPA becomes a hotspot to be applied in testing tumor related gene deletions/duplications mutations.

Key words: MLPA, Tumor related gene, Deletions/duplications, Detection