Abstract: Objective To investigate the expression of CMTM3 in human hypertophic myocardium, and the mechanism of hypertrophic cardiomyopathy. Methods The objects of this study consists of two parts:1). mouse model with cardiac hypertrophy induced by Isoproterenol(ISO) injection with 15mg/kg per day ;2). 32 cases of myocardial tissues from patients with hypertrophic cardiomypathy who were received surgery to clear the left ventricular outflow tract from January 2014 to June 2014 in Beijing Fuwai Cardiovascular Disease Hospital and 3 cases of normal myocardial tissues. RT-PCR, Real-time PCR and Western blot were used to detect the expression of CMTM3 in protein and transcriptional levels. Results 1).Compared with the wild-type mice treated with normal saline, the expression of Cmtm3 mRNA is down regulated. 2). Compared to normal myocardium, the expression of CMTM3 is down regulated both in transciptional and protein levels . Conclusion CMTM3 may play important role in regulating the occurrence of hypertrophic cardiomypathy.

Key words: CMTM3, hypertrophic cardiomyopathy