Abstract: Objective To study plasma levels of cysteine-rich protein 61(CYR61) in coronary artery disease (CAD) patients and evaluate their association with clinical data. Method Plasma level of CYR61 was measured in 97 patients with CAD (48 patients with acute coronary syndrome (ACS) and 49 with stable angina pectoris(SAP)) and 49 controls with negative CAG results. Results Plasma levels of CYR61 were higher in patients with CAD (10.47ug/L versus 4.55ug/L, P<0.01) and CYR61 was an independent risk factor of coronary artery disease (OR 1.164， 95%CI 1.065 ~ 1.273，P<0.01). CYR61 levels in ACS group were significantly higher than those in SAP group (15.61ug/L versus 8.03ug/L, P<0.01). CYR61 was positively related with Gensini score (P<0.01).Conclusions CYR61 may have a relationship with the development of coronary artery disease and the type and severity of coronary artery disease.

Key words: Cysteine-Rich Protein 61, Coronary disease, Atherosclerosis