Abstract: Traditional research ideas of miRNA-target gene-biological function have ignored the contact between the target genes and signaling pathways they are involved, making the integrity and relevance of miRNA regulatory mechanisms not be fully elucidated. Integrated with systematic and relevant way of thinking, summarization and analysis for the luciferase reporter assay validated miR-205 target genes and their related signaling pathways will pave the way for new research area for miR-205, and, it will be helpful for breaking through the status quo and exploring the novel research areas for miRNA.

Key words: miR-205, target genes, research progress and trend