Abstract: Objective Crohn’s disease (CD) is a chronic inflammatory disease involving the gastrointestinal tract with a tendency toward remission and relapse, and sometimes hardly be diagnosed until taken operation. It is said that 18F-PET/CT is a novel non-invasive technique for differential diagnosis and assessment of Crohn’s disease. Methods 3 patients were included from June 2012 to Augest 2012 in PUMCH, all have done the 18F-PET/CT. Results Patient 1, there were many abnormal areas with high FDG uptake in intestinal tract which standardized uptake value (SUVmax) were similar to in liver. Patient 2, the SUVmax was twice higher than in liver. Patient 3, it was more than 4-fold. Patient 1 and 2 were considered as CD, and patient 3 was T-cell lymphoma. Conclusions 18F-PET/CT is a novel non-invasive technique, but high-tech and expensive, for patient who is suspected for CD .

Key words: Key words：Crohn’s disease, PET/CT, diagnosis, assessment , non-invasive