Abstract: Objective This study aimed to screen the early-warning plasma biomarkers of cervical intraepithelial neoplasiaⅡ/Ⅲ stage (CINⅡ/Ⅲ) in Uygur women by using Ingenuity Pathway Analysis (IPA), as well as explain the canceration mechanism of cervical cancer. Methods 31 plasma differentially expressed proteins which were analyzed and identified by proteomic techniques were performed by functional annotation, networks analysis, biofuction analysis, canonical pathways analysis and IPA–biomarker? filter analysis using IPA@ online bioinformatics software. Results As the result of IPA@ analysis, when classified according to function, inflammatory response, cell to cell signaling and interaction, cellular growth and proliferation were most frequently identified in CINⅡ/Ⅲ. Acute phase response signaling and JAK/Stat signaling and IL-4 signaling,etc were identified as the canonical pathways that are overrepresented in CINⅡ/Ⅲ. Two plasma proteins (ApoAⅠ and mTOR) as candidate biomarker were screened. Conclusion The proteins ApoAⅠand mTOR could considered as candidated plasma markers of cervical cancer and cervical precancerous lesion.

Key words: Uyghur women, cervical intraepithelial neoplasia, IPA@ bioinformatics analysis, plasma biomarkers.