Abstract: The sequence of miR-100 is highly conserved. In most of the literature about solid tumor, decreased expression of miR-100 were reported, and increase the expression show inhibitory effects on tumor cells. But also, there are reports that over expresstion correlated with tumor recurrence. Still, there are different views on the relationship between the expressions of miR-100 with the pathological staging and disease progression. Several targets have been confirmed, that control the cell proliferation, cell cycle and apoptosis, and regulate the sensitivity of cancer cells to chemotherapy and radiotherapy.

Key words: cancer, miR-100, target