Abstract: Gastric carcinoma is characterized by genomic instability, researches show that genomic instability play significant roles in the pathological process of chronic atrophic gastritis, gastric ulcer, atypical hyperplasia, intestinal metaplasia and gastric carcinoma. Above all, relevant researches will provide new guidance for the earlier diagnosis, immunotherapy and prognostic evaluation of gastric cancer.

Key words: genomic instability, microsatellite instability, chromosomal instability, gastric carcinoma, precancerous lesions