Abstract: Antimicrobial peptides have been shown to serve as immediate first-line defense against potential pathogens in the skin. The antibacterial mechanism of cationic antimicrobial peptides in skin disease process has been extensively studied，but anionic antimicrobial peptides is relatively unknown. The role of antimicrobial peptides in epidermal immunity and low predilection for developing bacterial resistance has been studied extensively thus far, the potential health benefits of the use of synthetic bioactive peptides is promising in dermatological disease. But some technical obstacles must be overcome before they can be successfully translated into therapeutics.

Key words: bioactive peptides, antimicrobial peptides, dermatology, therapeutics