Abstract: Members of the transforming acidic coiled-coil (TACC) family of proteins have been implicated in tumor and are concentrated at centrosomes. TACC proteins involve in regulation of genome stability and gene transcription which could make important contributions to the development of tumor. But the existing research is not yet clear about the role of TACC proteins in tumor. This review will discuss the recent progress in their role, particularly the mechanism of regulation in tumor development.

Key words: TACC protein, stability of genome, gene transcription