Abstract: Objective To evaluate the relative clinical characteristics, therapy and prognosis of cervical small cell carcinoma. Methods Fourteen patients diagnosed with cervical small cell carcinoma were treated at Peking Union Medical College Hospital (PUMCH) from Apr, 2006 to Mar, 2012. The demographic, treatment and survival information were retrospectively reviewed. Follow-up and survival data was also collected. Results The median age of the patients was 38 years (26-66years). 13 patients were premenstrual, and the other one was postmenstrual. 5 patients were FIGO stage Ib1, 3 were Ib2, one was IIa2, 2 were IIb, and 3 were IVb. 10 patients were given radical hysterectomy and/or bilateral salpingo-oophorectomy (BSO) and/or lymphadenectomy, and one FIGO stage IVb patient was given hysterectomy. All the patients received platinum-based chemotherapy. 4 patients with stage Ib1—IIa2 were given adjuvant radiation after radical hysterectomy and 2 patients (stage IIb and IVb) were given radical radiation. With the follow-up time of 3-51months, 7 of 9 patients with stage Ib1—IIa2 alived without disease recurrence, and the other 2 patinets with stage Ib1 and Ib2 developed pulmonary metastasis with disease-free survival (DFS) 10 and 9 moths respectively. One stage IIb patient developed pelvic recurrence at 19 months. The other 4 patients with stage IIb—IVb died of the disease with the overall survival 5—12 months. Conclusion Cervical small cell carcinoma is a kind of highly aggressive neuroendocrine carcinoma and prone to metastasize early. The patients should be treated by multidisciplinary therapy, including surgery, chemotherapy and radiotherapy.