Abstract: Objective To investigate the effects of the aldosterone receptor antagonism spironolactone on the relationship between MMPs/TIMPs expression and activity remodeling after myocardial infraction(MI),to explore the molecular mechanism for the prevention of heart failure after MI,and provide a theoretical basis and new ideas. Methods: Myocardial infarction model were set up by drug intervention.Histopathology was detected by HE staining. Immunohistochemical and RT-PCR were used to observe the gene and protein expression of MMP-2,MMP-9,TIMP-2. Results: Post infarction both compare MI and control MMP-2,MMP-9 ,TIMP-2 was increased significantly in 48h,remain maintain higher level in 4 weeks(P<0.01). MMP-2 and MMP-9 patency fallout ,TIMP-2 no-apparent fallout by spirolactone interference. Conclusion: Spirolactone can decreased transcription and expression of MMP-2,MMP-9 / TIMP-2 activity in myocardial noninfarct area of rat.

Key words: keywords: myocardial infarction, spirolactone, matrix metalloproteinases, tissue inhibitors of metalloproteinases, ventricular remodeling