Abstract: Alpha-synuclein oligomers are the main composition of the Lewy body in patients with Parkinson’s disease, and they may be associated with oxidative stress damage and oxidative modification. The oxidative modifications include nitrative modification and dopamine oxidative adduction. Serving as a biomarker, α-synuclein may become a new target for clinical treatment.

Key words: α-synuclein, oxidative stress, oxidative modification, Parkinson’s disease