Abstract: Abstract: Objective To study the effects of Donepezil Hydrochloride on the expression of TGF-β、βFGF in the Hippocampal Neurons of Mice with Vascular Dementia. Methods 120 SD mice were divided into shame group（Shame）,model group(Model) and treatment group with donepezil hydrochloride (Drug)randomly after the water maze test .The rat model of the vascular dementia was made by a Permanent bilateral occlusion of both common carotids arteries using 2-VO method. The expression of TGF-β and βFGF in hippocampus CA1 were observed by immunohistochemistry technique. The expression of apoptosis neuron were observed by TUNEL technique. Results The expression of TGF-β（128.45±6.23）, βFGF（80.95±9.48） in hippocampus CA1 was significantly higher in the drug group than that in the model group（142.93±10.22;110.45±9.75.p<0.05）.The expression of apoptosis neuron was low in the shame group and the drug group, but high in the model group. Conclusion Donepezil hydrochloride can increase the expression of TGF-β and βFGF, reduce the apoptosis neuron, and furthermore improve the abilities of learning and memory.

Key words: Key words: Donepezil Hydrochloride, Vascular Dementia, TGF-β, βFGF, apoptosis