Abstract: Abstract:Objective To explore the value of vibration response imaging (VRI) system in evaluating the patients with diffuse parenchymal lung disease (DPLD).Methods 35 DPLD patients that their CT show reticulation and honeycombing in the base of the lung and 33 healthy volunteers were enrolled,Clinical examination and VRI test were performed.The parameters of VRI included vibration energy graph grades, dynamic image grades,areas of Maximal energy frame(MEF), quantitative lung data(QLD) and crack .The statistical analysis was performed using 2 Independent Samples Tests and Independent-Samples T test.Results The VRI parameters of the DPLD group were as follows,ie.graph grades of 2(1~3),dynamic image grades of 3(2~4),MEF areas of (71.13±4.94)kilo-pixels,QLD of （54.31±11.34）%(left).The VRI parameters of the control group were as follows,ie. graph grades of 0(0~1),dynamic image grades of 0(0~1),MEF areas of (71.61±3.42)kilo-pixels,QLD of（56.70±6.02）% (left) .There were significant differences in graph grades and dynamic image grades(P<0.05) ,otherwise MEF areas and QLD were not.Energy move down during inspiration in DPLD patients.Crack detectation was consistent with auscultation in 89% subjects.Conclusion VRI results of DPLD patients that their CT show reticulation and honeycombing in the base of the lung have its characters.there was a statistical difference between the VRI results of DPLD patients and healthy subjects.VRI will be helpful in diagnosing DPLD during its early stage.

Key words: Diffuse parenchymal lung disease, Vibration response imaging, Respiratory sounds