Abstract: Abstract：Objective To observe the expression and sites of FGF10 and FGFR2 Ⅲb during kidney development of mouse, in order to investigate their roles in kidney development. Methods Immunohistochemistry technique and Western blotting method were used to observe the expression of FGF10 and FGFR2 Ⅲb at embryonic day 12、14、16、18 and neonatal day 1、7、14、21、42 in the developing mouse kidney. Results FGF10 and FGFR2 IIIb were weakly expressed in the ureteric buds at E12d and then with the renal development, FGF10 and FGFR2 IIIb were expressed mainly in distal tubules and collecting ducts. FGF10 was expressed also in the proximal convoluted tubule. FGFR2 IIIb was not expressed in the proximal tubule. The renal corpuscles in each development stage were not found the expression of FGF10 and FGFR2 IIIb. Western blot showed that during kidney development, the expressions of FGF10 and FGFR2 IIIb were increased firstly and then decreased. Conclusions FGF10 and FGFR2 IIIb probably play an important role in the renal development.

Key words: FGF10, FGFR2Ⅲb, Kidney development, Mouse